Skip to main content
. Author manuscript; available in PMC: 2016 Nov 15.
Published in final edited form as: Biol Psychiatry. 2015 Feb 7;78(10):693–701. doi: 10.1016/j.biopsych.2015.01.015

Figure 1. 5LO protein levels are elevated in brains from human tauopathy and transgenic tau mice.

Figure 1

(A) Representative Western blot analyses for 5LO in brain cortex homogenate from Control and Progressive Supranuclear Palsy (PSP) patients. (B) Densitometric analyses of the immunoreactivity to the antibodies in panel A (*p<.001) (C) Representative Western blot analyses for 5LO in brain cortex (CTX) homogenates from wild type (WT) and htau mice at 2,6,10 and 16 months of age. (D) Densitometric analyses of the immunoreactivity to the antibody in panel C (*p<.001; **p<.0001) (E) Representative Western blot analyses for 5LO in brain cerebellum (CB) homogenates from WT and htau mice at 2,6,10 and 16 months of age. (F) Densitometric analyses of the immunoreactivity to the antibodies in Panel E. Results are mean ± sem (n= 6 per group).