Table 1.

Overview of the studies on the impact of pharmacotherapy on cognitive functions

References	Diagnose	No. of the patients	Studied compound	Duration of the study	Cognitive battery
Borkowska et al. (2007)	Major depressive disorder	71	Mirtazapine	6 months	Wisconsin Card Sorting Test, N-back test, TMT, Stroop Tests
Braszko et al. (2003)	Depressive symptoms in non-depressive patients	39	Captopril, enalapril	4 weeks	The Rey Auditory Verbal Learning Test, Wechsler Memory Scale
Chang et al. (2012)	Major depressive disorder	149	Fluoxetine, venlafaxine	6 weeks	Continuous Performance Test (CPT), Finger-Tapping Test (FTT), and Wisconsin Card-Sorting Test (WCST)
Constant et al. (2005)	Major depressive disorder	20	Sertraline	7 weeks	Phasic Alertness Task, Stroop Test, The Supraliminal and Subliminal Emotional Stroop,
Galassi et al. 2006	Major depressive disorder	48	Fluoxetine, reboxetine	6 months	Attentional matrices, Wechsler memory scale, Familial faces recognition, Famous faces recognition, Stem completion test, Autobiographical memory, MLT ‘88: test for historical events, MMSE
Gorenstein et al. (2006)	Major depression	42	Imipramine, clomipramine, fluoxetine, sertraline	>6 months (imipramine for 2.4 ± 0.6 years, clomipramine for 2.8 ± 1.2 years, fluoxetine for 1.8 ± 0.3 years, sertraline for 1.5 ± 0.3 years)	Subjective Memory Questionnaire (SMQ), Verbal recall, Word appreciation task, Digit span forward and backward, Word stem completion, Visual recall (from Memory I, PSS), Digit–Symbol Substitution Test (DSST), Cancellation Task (CT), Symbol Copying Test (SCT), Tapping (from Vienna Test System), Inserting pins (from Vienna Test System), Reaction times (from Foundations I, PSS)
Gualtieri et al. (2006)	Major depressive disorder	31	Citalopram, fluoxetine, escitalopram, paroxetine, mirtazepine, trazodone, venlafaxine, bupropion, sertraline	4 weeks	Finger Tapping Test, Symbol-digit Cod, Stroop Test, The Shifting Attention Test, Continuous Performance Test
Han et al. (2011)	Major depression	281	Fluoxetine, sertraline, fluvoxamine, paroxetine and citalopram, amitriptyline, desipramine, doxepine, imipramine, nortriptyline, trimipramine clomipramine, maprotiline, tranylcypromine, trazodone, nefazodone, venlafaxine, bupropion	12 months	Mini-Mental State Examination
Herrera-Guzmán et al. (2009)	Major depressive disorder	73	Escitalopram, duloxetine	24 weeks	WAIS III vocabulary subtest, WAIS III digit span, Rey auditory verbal learning test (RAVLT), Pattern recognition memory (PRM), Spatial recognition memory (SRM), reaction time (RTI)
Herrera-Guzmán et al. (2010)	Major depressive disorder	73	Escitalopram, duloxetine	24 weeks	WAIS III vocabulary subtest, WAIS III Digit span, Spatial Working Memory (SWM), Rapid Visual Information Processing (RVIP), Match to Sample Visual Search (MTS), Stroop Test, Intra–Extra-Dimensional Set Shift (ID/ED), Stockings of Cambridge (SOC)
Klasik et al. (2011)	Major depressive disorder	20	Tianeptine	3 months	Vienna Test System
Levkovitz et al. (2012)	Major depressive disorder	46	SAMe (adjunctive to SRI drug)	6 weeks	Cognitive and physical symptoms questionnaire (CPFQ)
Pedrelli et al. (2010)	Major depression disorder	117	Tricyclic antidepressants, benzodiazepines, mirtazapine	>10 months	CPFQ
Pelton et al. (2008)	Depression (major depressive disorder, dysthymic disorder, or depression not otherwise specified	23	Donepezil	12 weeks	Buschke Selective Reminding Test (targeting memory), WAIS-III digit symbol, Trails B (executive function), CFL (verbal fluency), Trails A (attention/psychomotor speed)
Raskin et al. (2007)	Major depressive disorder	311	Duloxetine	8 weeks	Verbal Learning and Recall Test, the Symbol Digit Substitution Test, the Two-Digit Cancellation Test, the Letter-Number Sequencing Test
Schrijvers et al. (2009)	Major depressive disorder	19	Sertraline	6 weeks	Computed copying tasks, Symbol Digit Substitution, Task (SDST, a subtest of the Wechsler Adult Intelligence Scale)