. 2015 Jun 3;5(4):332–345. doi: 10.1007/s13346-015-0239-x

Table 1.

Mean postprandial pharmacokinetic parameters for 3-day ID and SC infusion of insulin aspart across treatment days/meals and for individual treatment days (n = 141–156)

Parameter	Route	Days 1–3 combined (mean ± SD)	p value	Day 1	Day 2	Day 3
Primary endpoint
Tmax [min]	ID	28.5 ± 13.2	<0.0001	27.6 ± 13.9	29.1 ± 13.3	29.1 ± 12.5
Tmax [min]	SC	47.7 ± 22.8	<0.0001	46.0 ± 28.4	50.1 ± 19.7	47.1 ± 18.3
Secondary endpoints
T50_max_rising [min]	ID	6.0 ± 2.4	<0.0001	5.7 ± 2.2	5.8 ± 2.6	6.4 ± 2.3
T50_max_rising [min]	SC	12.2 ± 7.7	<0.0001	13.2 ± 7.9	12.0 ± 9.5	11.2 ± 5.0
T50_max_falling [min]	ID	107 ± 36.1	<0.0001	108 ± 39.2	106 ± 32.6	107 ± 36.7
T50_max_falling [min]	SC	138 ± 45.1	<0.0001	135 ± 51.1	143 ± 44.1	136 ± 39.5
ΔCmax [mU/L]	ID	57.9 ± 46.5	0.0121	54.5 ± 42.1	58.6 ± 47.0	61.2 ± 51.5
ΔCmax [mU/L]	SC	48.7 ± 37.6	0.0121	47.4 ± 37.5	47.2 ± 34.8	51.5 ± 40.8
ΔAUCIns₀₋₁ [mU*h/L]	ID	42.5 ± 34.7	<0.0001	39.5 ± 31.4	43.7 ± 36	44.8 ± 37.4
ΔAUCIns₀₋₁ [mU*h/L]	SC	31.3 ± 24	<0.0001	29.9 ± 25.3	30.6 ± 21.1	33.6 ± 25.7
ΔAUCIns_0–1.5 [mU*h/L]	ID	60.2 ± 51.6	0.0039	56.6 ± 46.4	61.6 ± 54.0	62.8 ± 55.6
ΔAUCIns_0–1.5 [mU*h/L]	SC	49.0 ± 39.0	0.0039	45.9 ± 38.9	48.7 ± 35.9	52.8 ± 42.5
ΔAUCIns_0–2 [mU*h/L]	ID	72.5 ± 65.5	NS	68.5 ± 59.0	74.0 ± 67.8	75.7 ± 71.2
ΔAUCIns_0–2 [mU*h/L]	SC	62.2 ± 52.3	NS	57.8 ± 50.9	62.6 ± 49.6	66.7 ± 57.0
ΔAUCIns_0–4 [mU*h/L]	ID	91.0 ± 93.5	NS	86.9 ± 85.8	92.3 ± 94.5	94.4 ± 103
ΔAUCIns_0–4 [mU*h/L]	SC	83.4 ± 81.3	NS	77.4 ± 76.2	85.7 ± 82.3	87.7 ± 86.9

Significant difference p < 0.05

NS not significant