Table 2.

Liver function tests and fasting lipid profile of participants by study arm

Laboratory parameter, Median (IQR)	Week	Placebo	Active drug	P-value†
AST (U/l)	0	35.8 (25.3, 55.9)	35.8 (24.5, 43.8)	0.458
	12	32.8 (25.9, 44.3)	32.6 (25.6, 44.6)	0.852
	16	34.6 (26.5, 45.9)	33.3 (26.9, 41.4)	0.561
	28	32.3 (23.7, 49.0)	32.1 (23.6, 45.4)	0.458
ALT(U/l)	0	18.1 (11.1, 32.9)	15.6 (11.1, 32.9)	0.694
	12	15.1 (9.1, 20.6)	13.3 (6.2, 17.6)	0.272
	16	16.0 (12.6, 26.3)	15.9 (10.9, 23.4)	0.319
	28	14.6 (7.2, 19.9)	11.9 (7.2, 21.1)	0.948
HDL (mmol/l)	0	1.7 (1.5, 2.0)	1.7 (1.6, 1.8)	0.726
	12	1.7 (1.5, 2.0)	1.5 (1.2, 1.9)	0.113
	16	1.9 (1.6, 2.5)	1.6 (1.6, 2.0)	0.492
	28	1.5 (1.3, 1.6)	1.5 (1.3, 1.8)	0.380
LDL (mmol/l)	0	4.9 (2.4, 6.7)	3.1 (2.2, 4.9)	0.222
	12	4.2 (2.1, 6.4)	1.0 (0.9, 2.5)	0.0006***
	16	3.8 (2.5, 6.4)	2.3 (1.9, 4.8)	0.097
	28	1.9 (1.3, 3.1)	2.1 (1.7, 5.1)	0.239
Triglycerides (mmol/l)	0	2.0 (1.4, 3.2)	1.6 (1.1, 2.4)	0.089
	12	1.7 (0.9, 2.2)	1.0 (0.7, 2.1)	0.014*
	16	2.6 (1.3, 3.5)	1.7 (1.2, 2.8)	0.178
	28	1.5 (1.2, 2.1)	1.5 (1.2, 2.3)	0.663

^†Mann–Whitney test.

^*P value < 0.05,

^***P value < 0.001

AST, Aspartate aminotransferase, normal range 0–40 μl; ALS, alanine aminotransferase, normal range 0–40 μl; HDL, high-density lipoprotein, normal range 1–1.8 mmol/l; LDL, low-density lipoprotein, normal range up to 4.4 mmol/l.