Figure 2.

Leg plasma FGF-21 kinetics in young men (n = 9) during one-legged exercise. At baseline, there is no arterial-venous difference (A) or net production/uptake of FGF-21 (B) over neither leg. During exercise, plasma FGF-21 increases (C) and the arterial-venous differences across the exercising leg (D) increases. Net muscle uptake is not significantly increased in the exercising leg (E). * significant by one-way ANOVA. # significant by one-way ANOVA and Dunnett's post hoc test. † significant by Student's t-test. p < 0.05 was considered statistically significant. Data are presented as mean ± SEM. In (A) and (B) individual data are presented.