Table 5.
Genes downregulated in resistant LICR-HN5 R9.1 and SC263 R10.2 cells compared with sensitive LICR-HN5 PBS and SC263 PBS cells. Genes were selected based on fold change > 2
| Gene Symbol | Gene Name | Fold Change |
|---|---|---|
| HTRA1 | HtrA serine peptidase 1 | 3.45 |
| KRTDAP | keratinocyte differentiation-associated protein | 3.28 |
| PRODH | proline dehydrogenase (oxidase) 1 | 3.10 |
| KRT14 | keratin 14 | 2.79 |
| CXCR7 | Atypical Chemokine Receptor 3 | 2.77 |
| SPRR1B | small proline-rich protein 1B | 2.74 |
| ABCG1 | ATP-binding cassette, sub-family G (WHITE), member 1 | 2.60 |
| H19 | H19, imprinted maternally expressed transcript (non-protein coding) | 2.56 |
| AGR2 | anterior gradient 2 | 2.50 |
| SCGB1A1 | secretoglobin, family 1A, member 1 (uteroglobin) | 2.50 |
| MMP10 | matrix metallopeptidase 10 (stromelysin 2) | 2.43 |
| KRT13 | keratin 13 | 2.37 |
| KRT16 | keratin 16 | 2.31 |
| GJA1 | gap junction protein, alpha 1, 43 kDa | 2.30 |
| NTS | neurotensin | 2.30 |
| SLC7A8 | solute carrier family 7 (amino acid transporter light chain, L system), member 8 | 2.28 |
| TSC22D3 | TSC22 domain family, member 3 | 2.27 |
| SPANXC | SPANX family, member C | 2.19 |
| TNFSF10 | tumor necrosis factor (ligand) superfamily, member 10 | 2.18 |
| GPNMB | glycoprotein (transmembrane) nmb | 2.18 |
| PTPRZ1 | protein tyrosine phosphatase, receptor-type, Z polypeptide 1 | 2.15 |
| TP63 | tumor protein p63 | 2.15 |
| PPAP2B | phosphatidic acid phosphatase type 2B | 2.14 |
| SESN3 | sestrin 3 | 2.12 |
| IGFBP2 | insulin-like growth factor binding protein 2, 36 kDa | 2.10 |
| PI3 | peptidase inhibitor 3, skin-derived | 2.10 |
| BMP7 | bone morphogenetic protein 7 | 2.10 |
| MYLIP | myosin regulatory light chain interacting protein | 2.10 |
| CLCA2 | chloride channel accessory 2 | 2.10 |
| CXCR7 | atypical chemokine receptor 3 | 2.09 |
| SPRR1A | small proline-rich protein 1A | 2.07 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | 2.07 |
| DOCK8 | dedicator of cytokinesis 8 | 2.06 |
| AMTN | amelotin | 2.04 |
| ALDH3A1 | aldehyde dehydrogenase 3 family, member A1 | 2.04 |
| SREBF1 | sterol regulatory element binding transcription factor 1 | 2.03 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 2.03 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 2.02 |
| SOX21 | SRY (sex determining region Y)-box 21 | 2.01 |
| S100A8 | S100 calcium binding protein A8 | 2.00 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | 2.00 |
| SCG2 | secretogranin II | 2.00 |