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. Author manuscript; available in PMC: 2016 Jul 21.
Published in final edited form as: Immunity. 2015 Jul 7;43(1):52–64. doi: 10.1016/j.immuni.2015.04.022

Figure 3. miR-155-mediated SOCS1 regulation is critical to maintain normal Treg and Tconv cell numbers in a competitive setting.

Figure 3

(A)Ratios of frequencies of CD45.1−Foxp3+ and CD45.1+Foxp3+ Treg cells within each donor-derived CD4+ T cell population from peripheral blood lymphocytes 100 days after BM transfer. (B) Treg cell frequencies within each donor-derived T cell population from both the thymus and spleen 120 days after BM transfer. (C) Ratios of frequencies of thymic and splenic CD45.1-Foxp3+ and CD45.1+Foxp3+ Treg cells within each donor-derived CD4+ T cell population 120 days after BM transfer. Ratios of frequencies of CD45.1−Foxp3− and CD45.1+Foxp3−(D) CD4+ and (E) CD8+ Tconv cells within each donor-derived compartment from peripheral blood lymphocytes 100 days after BM transfer. Each symbol represents an individual mouse, and the data are shown as mean ± SD.