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. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: Mol Immunol. 2015 Apr 28;67(2 0 0):142–152. doi: 10.1016/j.molimm.2015.04.001

Figure 4. Fluorescence-guided resection of tumors.

Figure 4

By probing with a fluorescently-labeled antibody for a tumor marker, surgeons can immediately determine whether a tumor has been fully resected, and identify local metastases that may not be visible by eye. Here, a far-red fluorescent dye (Cy5)-labeled anti-PSCA diabody was used to guide resection of an intramuscular 22rv1-PSCA prostate cancer xenograft in a murine model. Cy5-anti-PSCA diabody was injected intravenously and surgery was performed 6 hours post-injection. (A) A white-light image of the tumor bed post-resection, with residual tumor purposely left unresected. (B) Fluorescence imaging shows residual tumor clearly. (Behesnilian et al., 2015)