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. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: Mol Immunol. 2015 Apr 28;67(2 0 0):142–152. doi: 10.1016/j.molimm.2015.04.001

Figure 5. Dual-modality antibody imaging.

Figure 5

Non-invasive staging of lymph nodes (LN) followed by image-guided resection of only cancer-positive LNs offers more precision in identifying and removing metastases. Hall et al. used a dual-labeled anti-EpCAM mAb, conjugated with both IRDye 800CW and 64Cu-DOTA, to image prostate cancer LN metastases with PET/CT (A) and NIR fluorescence (B) imaging. PC3 cells were implanted in the prostate and imaging was performed 10–12 weeks later. Lumbar LNs (LLNs); renal LNs (RLNs); sciatic LN (SLN). This research was originally published in JNM. Hall MA et al. J Nucl Med. 2012;53:1427–37. © by the Society of Nuclear Medicine and Molecular Imaging, Inc.