. Author manuscript; available in PMC: 2016 Aug 1.

Published in final edited form as: Curr Opin Cell Biol. 2015 May 15;35:78–90. doi: 10.1016/j.ceb.2015.04.012

Table 1.

Spindle Assembly Factors (SAFs)	Examples	Refs.
MAPs	TPX2, NuMA, Xnf7, HURP, Maskin, NuSAP	[9]
Kinesins	⁽¹⁾XCTK2⁽²⁾Kid	[9]
Spindle Matrix Proteins	Lamin B, Rae1	[9] [20–22]
K-fiber stabilization	MCRS1^*	[26]
Tumor Suppressor	Adenomatous Polyposis Coli (Apc)^*	[23]
Chromatin Remodeling ATPases	CHD4^, ISWI^	[24] [25]
Multiple cellular functions	Nucleophosmin, Survivin, Cdk11	[9] [17]
NPC Proteins	Nup107–160 complex, Nup98^, ELYS/Mel28^	[38] [39] [42] [44]

NPC Assembly Factors	Examples	Refs.
Importin Beta and/or Transportin Regulated Nups	Nup107–160 complex, ELYS FG Nups (Nup358, Nup214, Nup153, Nup98, Nup62, Nup50)	[39][40] [50–52]

Ran Modulation Factors	Examples	Refs.
	RCC1, RanGAP, RanBP1^*, RanBP2, Sumo	[9] [19] [63]

⁽¹⁾

Spindle-Kinesin

⁽²⁾

Chromokinesin

The star (*) indicates recently characterized Ran- and/or Karyopherin- regulated SAFs