Table 1.
Spindle Assembly Factors (SAFs) | Examples | Refs. |
---|---|---|
MAPs | TPX2, NuMA, Xnf7, HURP, Maskin, NuSAP | [9] |
Kinesins | (1)XCTK2(2)Kid | [9] |
Spindle Matrix Proteins | Lamin B, Rae1 | [9] [20–22] |
K-fiber stabilization | MCRS1* | [26] |
Tumor Suppressor | Adenomatous Polyposis Coli (Apc)* | [23] |
Chromatin Remodeling ATPases | CHD4*, ISWI* | [24] [25] |
Multiple cellular functions | Nucleophosmin, Survivin, Cdk11 | [9] [17] |
NPC Proteins | Nup107–160 complex, Nup98*, ELYS/Mel28* | [38] [39] [42] [44] |
NPC Assembly Factors | Examples | Refs. |
Importin Beta and/or Transportin Regulated Nups |
Nup107–160 complex, ELYS FG Nups (Nup358, Nup214, Nup153, Nup98, Nup62, Nup50) |
[39][40] [50–52] |
Ran Modulation Factors | Examples | Refs. |
RCC1, RanGAP, RanBP1*, RanBP2, Sumo | [9] [19] [63] |
Spindle-Kinesin
Chromokinesin
The star (*) indicates recently characterized Ran- and/or Karyopherin- regulated SAFs