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. Author manuscript; available in PMC: 2016 Aug 1.
Published in final edited form as: Mol Cancer Ther. 2015 May 29;14(8):1896–1906. doi: 10.1158/1535-7163.MCT-14-0865

Figure 2. TMPRSS2-ERG enhances DNA damage and decreases the DNA repair kinetics.

Figure 2

Confocal immunostaining for (A) γH2AX and (B) 53BP1 foci following IR (10 Gy) treatment in PC3 parental and derivative cells expressing the TMPRSS2-ERG fusion gene. C, Quantification of the number of γH2AX, and 53BP1 foci at the indicated times. P < 0.0001 was calculated by two-way ANOVA. Error bars represent SD (n=3). D, TMPRSS2-ERG-V5 tag expression was detected with antibody against the V5-tag and the V5-TMPRSS2-ERG expression specificity examined by its siERG-mediated down-regulation.