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. Author manuscript; available in PMC: 2016 Aug 1.
Published in final edited form as: Mol Cancer Ther. 2015 May 29;14(8):1896–1906. doi: 10.1158/1535-7163.MCT-14-0865

Figure 6. TMPRSS2-ERG inhibits DNA-PKcs auto-phosphorylation and activity.

Figure 6

Confocal immunostaining for phospho-DNA-PKcs Thr2609 at the indicated times following IR in VCaP (A) and PC3 cells (B), with or without expression of the TMPRSS2-ERG fusion. C, Ser1778-53BP1 phosphorylation as a DNA-PKcs target was examined by confocal immunostaining following IR in PC3 parental and TMPRSS2-ERG-expressing derivative cells without (left) or following pre-treatment with NU7441 (right). Right side panels, represent quantification of the respective foci on the left. Error bars represent SD (n=3).