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Purinergic signalling is upstream of the eye field transcription factors (EFTFs) that are expressed very early in development of the frog embryo and to control development of the eye (see [364]). ATP released in the presumptive eye field is converted to ADP via NTPDase2. The ADP can activate the P2Y1 receptor (P2Y1R), which then triggers expression of the transcription factor Rx1
