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ASM mediates CD39 and CD161 intracellular signals and drives Th17 expansion. Under Th17 differentiation condition, MHC/CD3/28 and IL-6/IL-6R stimulations activate mTOR and STAT3 signals in CD4+ T cells. Meanwhile, stimulations of CD39 and CD161 further amplify ASM-mediated mTOR and STAT3 signals, which eventually drive Th17 expansion
