Fig. 1.

Effects of donepezil on senescence of HUVECs exposed to HG. a Chemical structures of donepezil. b Percentages of SA-ß-gal-positive HUVECs in different groups. c Donepezil rescued the arresting effects of HG on the cell cycle of HUVECs. d Cell cycle analysis was performed by FACS. The effects of donepezil on cell viability were examined by MTT assay, and cell viability was calculated as the percentage of control (*P < 0.01 vs. control group; #P < 0.01 vs. HG group). HG high glucose, NG normal glucose