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. Author manuscript; available in PMC: 2016 Aug 6.
Published in final edited form as: Cell Stem Cell. 2015 Aug 6;17(2):139–151. doi: 10.1016/j.stem.2015.07.008

Figure 6. TLR3 activation increases STAT3 occupancy of β-catenin and GLI2 promoters.

Figure 6

A) Mean fold change in β-catenin and GLI2 mRNA after continuous exposure to poly (I:C) at indicated time points as determined by qRT-PCR and normalized to housekeeping gene, RPLP0. Fold changes in mRNA expression relative to pre-confluent keratinocytes.

B) Relative fold enrichment of STAT3 occupation of β-catenin and GLI2 promoter sites after poly (I:C) treatment of keratinocytes. Negative binding sites also included below. Data representative of 5 independent experiments, p < 0.05.

C) Graphical representation of verified positive and negative STAT3 binding on β-catenin and GLI2 after poly (I:C) treatment of keratinocytes. Images obtained from ENCODE database.

*p < 0.05 by Student’s T-test or Single Factor ANOVA.