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. Author manuscript; available in PMC: 2016 Aug 1.
Published in final edited form as: J Allergy Clin Immunol. 2015 Aug;136(2):252–257. doi: 10.1016/j.jaci.2015.06.024

Table I.

In vitro assays for research examining the rationale of using specific tests at the onset of ADR.

Genetic assays
HLA-A (81)
HLA-B (82)
HLA-C (83)
HLA-DR (84)
HLA-DQ (85)
Immune-disease associated genes
T cell differentiation
IL2-IL21 (86)
Signaling
CTLA-4 (87)
Innate immunity
IFIH1 (88)
Cytokines
IL7R (24)
Drug metabolism genes
CYP34A (58)
CTP2C9 (59)
GCLC (61)
Nrf-2 (62)
Immunological assays

HSP70i (75)

RPL2A (76)

In vitro T cell–stimulation assays (77)

ELISPOT (78, 89)

 Subset analysis
  Th1: IL-2
  Th2: IL-4
  CD8: IFN-γ
  CD4/CD8: IL-8
Treg: IL-10

Flow cytometry (90, 91)

 Subset analysis
  CD4
  CD8
  CTLA-4
  Foxp3
Viral assays (detection/activation)
HHV-4
Epstein-Barr virus (EBV) (40)
HHV-5 Cytomegalovirus (CMV) (43)
HHV-6 Roseolovirus, Herpes lymphotropic virus (42)
HIV Human Immunodeficiency virus (41)