Table 3.
Infant characteristics and neurodevelopmental outcomes from ESA RCT
| Darbe (n=27) | Epo (n=29) | Placebo (n=24) | p | Adjusted Odds Ratio | p | |
|---|---|---|---|---|---|---|
| Birth Weight (grams) | 938.3 ± 176.5 | 947.2 ± 212.7 | 953.0 ± 210.0 | NS | ||
| Gestation (weeks) | 28.1 ± 1.8 | 27.8 ± 1.9 | 27.8 ± 1.6 | NS | ||
| Corrected age at follow up (months) | 20.5 ± 1.1 | 21.2 ± 2.0 | 20.6 ± 1.9 | NS | ||
| Composite cognitive | 96.2±7.5 | 97.9±14.0 | 88.7±13.3 | 0.01 | ||
| Composite language | 92.4±12.8 | 89.9±17.4 | 83.6±13.9 | 0.05 | ||
| Object permanence | 2.8±0.4 | 2.4±0.8 | 2.2±1.0 | 0.05 | ||
|
| ||||||
| Neurodevelopmental Impairment: | 3 (11%) | 2 (7%) | 9 (38%) | 0.18 (0.05 to 0.63) | 0.01 | |
| Cerebral Palsy (%) | 0 (0) | 0 (0) | 5 (21) | 0.002 | 0 (0 to 0) | <0.001 |
| Visual deficit (%) | 1 (4) | 0 (0) | 1 (4) | 0.09 | 0.23 (0.04 to 1.54) | NS |
| Hearing deficit (%) | 0 | 1 (3) | 1 (4) | 0.33 | 0.54 (0.11 to 2.65) | NS |
| Composite Cognitive Score<85 | 0 | 3 (10.3%) | 6 (25%) | 0.02 | 0.18 (0.04 to 0.78) | 0.01 |
| Composite Cognitive Score<70 | 0 | 1 (3.4%) | 2 (8.3%) | 0.29 | ||
Odds Ratios adjusted for gender. Values represent mean±SD or number (percent). P values represent three way comparisons among groups.