Figure 1. Cluster of Clusters (CoC) Analysis.

The results of multiplatform analyses point to biologic subtypes defined by IDH mutation and 1p/19q codeletion status. CoC analysis uses the cluster assignments derived from individual molecular platforms to stratify tumors, thereby integrating data from analysis of messenger RNA (mRNA) (designated by R on the y axis), microRNA (mi), DNA methylation (M), and copy number (C). For each sample, membership in a particular cluster is indicated by a yellow tick, and nonmembership is indicated by a blue tick. CoC analysis resulted in a strong three-class solution, and a comparison of tracks for CoC consensus cluster with tracks for histologic and molecular class shows a stronger correlation with molecular class.