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. Author manuscript; available in PMC: 2015 Dec 25.
Published in final edited form as: N Engl J Med. 2015 Jun 10;372(26):2481–2498. doi: 10.1056/NEJMoa1402121

Figure 2. Mutational Landscape of Somatic Alterations in Lower-Grade Glioma.

Figure 2

At the top of the figure, somatic mutation rates for each patient are stratified according to nonsynonymous (blue) and synonymous (green) mutations. In the middle portion of the figure, the clinical features associated with the patients are shown. At the bottom of the figure, genes that are significantly mutated (q value <0.1, determined with the use of the MutSig2CV algorithm) in lower-grade glioma are listed on the right. Samples from patients have been separated according to IDH mutation and 1p/19q codeletion status, with mutation types indicated in specific colors. NA denotes not applicable.

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