Skip to main content
. Author manuscript; available in PMC: 2015 Dec 25.
Published in final edited form as: N Engl J Med. 2015 Jun 10;372(26):2481–2498. doi: 10.1056/NEJMoa1402121

Figure 3. OncoSign Analysis.

Figure 3

Four main classes (OncoSign classes [OSCs]) can be identified by means of unbiased clustering of tumors on the basis of recurrent copy-number alterations, mutations, and gene fusions. White indicates that no information was available. OSCs are largely consistent with the molecular subtypes identified on the basis of IDH mutation and 1p/19q codeletion status, and they also correlate with the results of single-platform analysis. Combinations of selected genomic events, termed oncogenic signatures, characterize each OSC. A small group of samples showed none of the recurrent events used in this analysis and were therefore categorized as unclassified. TERT promoter mutation and gene overexpression were found to be mutually exclusive with loss of ATRX and reduced gene expression, a finding consistent with the hypothesis that both alterations have a similar effect on telomere maintenance. The abbreviation miRNA denotes microRNA, and RPPA reverse-phase protein lysate array.

HHS Vulnerability Disclosure