Fig. 7.

Figure 4. Tribendimidine as an agonist of Ode-(29 – 8 – 38 – 63) and Ode-(29-63-38) receptors expressed in oocytes, currents recorded under voltage-clamp at −60 mV (Buxton et al., 2014b) A: Tribendimidine and pyrantel at 100 µM is more potent than levamisole on the Ode(29 – 38 – 63) receptor. B: Levamisole at 100 µM is more potent than acetylcholine tribendimidine, pyrantel and nicotine on the expressed Ode(29 – 8 – 38 – 63) receptor. Note that derquantel produces competitive antagonism of the effects of levamisole but a non-competitive antagonism of pyrantel, suggesting that the mode of action of levamisole and pyrantel are not identical.