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. Author manuscript; available in PMC: 2016 Aug 15.
Published in final edited form as: J Immunol. 2015 Jul 1;195(4):1868–1882. doi: 10.4049/jimmunol.1402243

Figure 9. Verticillin A up-regulates DR5 expression to increase metastatic human colon carcinoma cells to DR5 agonist antibody-induced apoptosis.

Figure 9

A. The indicated tumor cells were treated with verticillin A for 2 days and analyzed for DR4 and DR5 expression levels by flow cytometry. B. LS411N-5FU-R and SW620-5FU-R cells were treated with verticillin A (20 nM), Drozitumab (500 ng/ml) or both verticillin A and Drozitumab for 24h and analyzed for apoptosis by staining with Annexin V and PI. C. Quantification of apoptosis. % apoptotic cell death is expressed as % Annexin V+PI+ cells of the treated group - % Annexin V+PI+ cells of untreated control. ** p<0.01.