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. Author manuscript; available in PMC: 2016 Aug 1.
Published in final edited form as: J Mol Cell Cardiol. 2015 May 22;85:104–116. doi: 10.1016/j.yjmcc.2015.05.012

Figure 5. Impact of MnTBAP on mitochondrial function and myocardial substrate metabolism in 9 week-old db/db mice.

Figure 5

A–C. Oxygen consumption, ATP synthesis, and ATP/O ratios measured using saponin-permeabilized LV fibers with palmitoyl-carnitine and malate as substrates (n=6–8). D–F. Palmitate oxidation, cardiac power and mVO2 measured ex vivo in isolated working hearts (n=4–5). *p<0.05 vs. all other or indicated groups.

Inline graphic Saline-treated control wildtype (WT) mice, Inline graphic MnTBAP-treated WT mice, Inline graphic db/db treated with saline, Inline graphic db/db treated with MnTBAP. Dw=dry weight.