A–C. Oxygen consumption, ATP synthesis, and ATP/O ratios measured using saponin-permeabilized LV fibers with palmitoyl-carnitine and malate as substrates (n=6–8). D–F. Palmitate oxidation, cardiac power and mVO2 measured ex vivo in isolated working hearts (n=4–5). *p<0.05 vs. all other or indicated groups.
Saline-treated control wildtype (WT) mice, MnTBAP-treated WT mice, db/db treated with saline, db/db treated with MnTBAP. Dw=dry weight.