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. Author manuscript; available in PMC: 2016 Aug 1.
Published in final edited form as: J Mol Cell Cardiol. 2015 Jun 12;85:229–239. doi: 10.1016/j.yjmcc.2015.06.006

Figure 1. Matrix metalloproteinase-9 (MMP-9) deletion reduces dilation of the left ventricle (LV) at days 5 and 7 post-myocardial infarction (MI).

Figure 1

A. MI resulted in increased end-diastolic volume in both groups at all time points (p<0.05). The change in end diastolic volume from baseline was significantly decreased in MMP-9−/− mice at day 5 and 7 post-MI. B. MI also resulted in increased end-systolic volume in both groups at all time points (p<0. 05). The change in end-systolic volume was significantly decreased in MMP-9−/− mice at day 7 post-MI. C. MI significantly reduced ejection fraction at all time points in both groups, and no significant differences were observed between the groups. D. MI led to a significant reduction in end-diastolic wall thickness in both groups, at each time-point (p<0.05), and no differences were observed between the WT and MMP-9−/− groups. Note that day 0–7 data is presented from serial images taken on the same mice, while day 28 data is from a different set of mice. (n=15–32 per group for day 0–7 groups and n=6 per group for day 28; #p<0.05 vs. corresponding baseline group, *p<0.05 vs. WT at corresponding day)