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. Author manuscript; available in PMC: 2016 Aug 1.
Published in final edited form as: J Mol Cell Cardiol. 2015 Jun 12;85:229–239. doi: 10.1016/j.yjmcc.2015.06.006

Figure 3. Increased infarct stiffness prevents stretch of the non-infarcted remote myocardium during isovolumic contraction and promotes stretch during diastolic filling.

Figure 3

A. Longitudinal stretch of the mid-ventricle portion of the myocardial wall during isovolumic contraction, as determined from speckle-tracking echocardiography, was not different between the wildtype (WT) and matrix metalloproteinase-9 null (MMP-9−/−) groups (n = 12–17 per group; p=0.097). B. Negative longitudinal stretch of the basal portion of the myocardial wall during isovolumic contraction was significantly reduced (n = 12–17 per group; p<0.05). C. Longitudinal stretch in the mid-ventricle was not correlated to increased circumferential stress under 20% equibiaxial stress as determined from biaxial mechanical testing (n=10). D. Longitudinal stretch was correlated to increased circumferential stress indicating that increased infarct stiffness enhances the stretch of the remote myocardium during diastole (n=10; p<0.05).