Table 3.

Multivariate EFS analysis of the effect of chemotherapy dose as a continuous variable by R-Maintenance status, when adjusted for TDD or DDI of the other chemotherapy and FLIPI.

Chemotherapy Dose	HR					Interaction***
	Relative Increase*	R-Maintenance	Estimate	95% CI	p-value	p-value
doxTDD1,**	89 units	No	0.81	(0.67, 0.97)	0.0254	0.0524
		Yes	1.28	(0.84, 1.97)	0.2560
cycTDD2	1483 units	No	0.91	(0.67, 1.23)	0.5271	0.3320
		Yes	1.33	(0.66, 2.69)	0.4331
doxDDI3,**	0.23 units	No	0.94	(0.89, 1.00)	0.0458	0.2782
		Yes	1.02	(0.90, 1.15)	0.7921
cycDDI4	5.02 units	No	0.87	(0.61, 1.24)	0.4292	0.5854
		Yes	1.02	(0.66, 1.57)	0.9480

Adjusted for flipi and

¹cycTTD,

²doxTDD,

³cycDDI, or

⁴doxDDI.

^*HRs are reported for 1 standard deviation increases in dose.

^**Values of dox were set to zero for patients in which it was not used.

^***Interaction p-values are for the interactions between R-Maintenance and chemotherapy dose.