Table 1.
Number of Rats Intracranially Infected with Different Activated Taenia solium Oncosphere Doses Using Extraparenchymal (Type 1) and Intraparenchymal (Type 2) Routes
| No. of oncospheres | Extraparenchymal route∗ |
Intraparenchymal route† |
P‡ | ||||
|---|---|---|---|---|---|---|---|
| No. (%) of rats with cysts/without cyst | No. (%) of ELISA-positive rats | No. (%) of WB-positive rats | No. (%) of rats with cysts/without cyst | No. (%) of ELISA-positive rats | No. (%) of WB-positive rats | ||
| 0 | 0/6 (0) | 0 | 0 | 0/6 (0) | 0 | 0 | |
| 30 | 3/3 (50) | 1 (33) | 1 (33) | 6/0 (100) | 5 (83) | 3 (50) | 0.05 |
| 60 | 3/3 (50) | 1 (33) | 3 (100) | 5/1 (83) | 5 (100) | 3 (60) | 0.23 |
| 90 | 4/2 (67) | 3 (75)§ | 3 (50)¶ | 1/5 (16.7) | 1 (100) | 1 (100) | 0.07 |
| 180 | 4/2 (67) | 2 (50) | 1 (25) | 5/1 (83) | 2 (40) | 3 (60) | 0.52 |
| 360 | 3/3 (50) | 3 (100) | 2 (67) | 5/1 (83) | 3 (60) | 4 (80) | 0.23 |
| 720 | 5/1 (83) | 5 (100) | 4 (80) | 5/1 (83) | 4 (80) | 4 (80) | 1.0 |
| Total | 22/14 (61) | 15/22 (68) | 14/22 (63) | 27/9 (75) | 20/27 (74) | 18/27 (66.7) | 0.21 |
ELISA, enzyme-linked immunosorbent assay; WB, Western blot.
∗
Type 1 inoculation at 2-mm depth.
†
Type 2 inoculation at 4-mm depth.
‡
P value of the two-sample test of proportions of rats that develop cysticerci in the brain between intraparenchymal and extraparenchymal route of infection.
§
One rat was ELISA positive and WB negative.
¶
One rat was WB positive and ELISA negative.