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. 2015 Aug;185(8):2194–2205. doi: 10.1016/j.ajpath.2015.04.021

Figure 1.

Figure 1

Liver regeneration is temporally prolonged in liver-specific knockouts of Wntless (Wls-LKO) after partial hepatectomy (PH). Immunohistochemistry (IHC) for proliferating cell nuclear antigen (PCNA) shows many positive cells at 3 to 4 days after PH in Wls-LKO (A), confirmed by the quantification of PCNA staining (B). C: A representative Western blot analysis shows higher cyclin-D1 expression in the Wls-LKO livers at 3 and 4 days after PH, with only minor differences evident at 5 days. D: Immunoprecipitation shows enhanced β-catenin and T-cell factor (TCF) 4 binding in Wls-LKO at 40 hours and 3 days after PH compared with control (Con). ∗P < 0.05. Original magnification, ×200 (A).