Fig. 1. (A, B) Effects of the topical application of N-acetylcysteine (NAC) (for 4 weeks) on skin hydration and transepidermal water loss (TEWL) in healthy volunteers. (C, D) Effects of the topical application of NAC on skin hydration and TEWL in atopic dermatitis (AD) patients. Skin hydration and TEWL were measured before and 4 weeks after the twice daily application of NAC or its control vehicle. Statistical analysis was performed using the Wilcoxon signed-rank test.
