Table 3. Logistic regression analysis for factors associated with ‘any CIg <2.8'.
| Variable | N | Any CIg <2.8 | Any CIg ≥2.8 | OR (95% CI) | P-value |
|---|---|---|---|---|---|
| Univariate | |||||
| B2M ⩾3.5 mg/l | 137 | 44/82 (54%) | 14/55 (25%) | 3.39 (1.61, 7.15) | 0.0013 |
| B2M >5.5 mg/l | 137 | 28/43 (65%) | 30/94 (32%) | 3.98 (1.86, 8.54) | 0.0004 |
| Hb <10 g/dl | 139 | 27/43 (63%) | 33/96 (34%) | 3.22 (1.52, 6.81) | 0.0022 |
| CRP ⩾8 mg/l | 139 | 27/45 (60%) | 33/94 (35%) | 2.77 (1.33, 5.76) | 0.0063 |
| LDH ⩾190 U/l | 139 | 21/31 (68%) | 39/108 (36%) | 3.72 (1.59, 8.69) | 0.0025 |
| BMPC% ⩾33% | 134 | 49/93 (53%) | 10/41 (24%) | 3.45 (1.52, 7.85) | 0.0031 |
| Cytogenetic abnormalities | 136 | 30/57 (53%) | 28/79 (35%) | 2.02 (1.01, 4.05) | 0.0468 |
| GEP70 high risk | 139 | 20/32 (63%) | 40/107 (37%) | 2.79 (1.23, 6.31) | 0.0136 |
| GEP80 high risk | 139 | 11/16 (69%) | 49/123 (40%) | 3.32 (1.09, 10.15) | 0.0352 |
| GEP MS subgroup | 139 | 4/20 (20%) | 56/119 (47%) | 0.28 (0.09, 0.89) | 0.0311 |
| GEP centrosome index ⩾3 | 139 | 41/69 (59%) | 19/70 (27%) | 3.93 (1.93, 8.02) | 0.0002 |
| Number of stem lines >2 | 139 | 11/17 (65%) | 49/122 (40%) | 2.73 (0.95, 7.87) | 0.0628 |
| Total LCR% >50% | 139 | 21/28 (75%) | 39/111 (35%) | 5.54 (2.16, 14.18) | 0.0004 |
| Multivariate | |||||
| B2M >5.5 mg/l | 132 | 28/42 (67%) | 29/90 (32%) | 3.04 (1.27, 7.25) | 0.0121 |
| CRP ⩾8 mg/l | 132 | 25/42 (60%) | 32/90 (36%) | 3.35 (1.40, 8.01) | 0.0065 |
| GEP centrosome index ⩾3 | 132 | 38/65 (58%) | 19/67 (28%) | 2.56 (1.12, 5.87) | 0.0263 |
| LCR% >50 | 132 | 20/26 (77%) | 37/106 (35%) | 4.97 (1.68, 14.72) | 0.0038 |
Abbreviations: B2M, beta-2 microglobulin; BMPC%, bone marrow plasma cell percentage; CRP, C-reactive protein; CI, confidence interval; GEP, gene expression profile; Hb, hemoglobin; LDH, lactate dehydrogenase; MS, MMSET; LCR%, light chain-restricted percentage; OR, odds ratio.
P-value from Wald χ2-test in logistic regression. NS2 multivariate results not statistically significant at 0.05 level. Univariate P-values reported if <0.1. Multivariate model uses stepwise selection with entry level 0.1 and variable remains if meets the 0.05 level. A multivariate P-value >0.05 indicates variable forced into model with significant variables chosen using stepwise selection.