Table 2.
Association between genotypic and allelic distributions of MUTYH gene polymorphisms and individuals with RA.
| SNP database ID | RA number (%) |
Controls number (%) |
P value/cP value | Odds ratio (95% CI) |
|---|---|---|---|---|
| rs3219463 | ||||
| G/G | 37 (19.3) | 76 (39.6) | 0.00006*/ | 0.41 (0.21–0.82) |
| G/A | 129 (67.2) | 94 (49.0) | 0.00024* | 1.16 (0.62–2.17) |
| A/A | 26 (13.5) | 22 (11.4) | 1.00 | |
| G allele | 203 (52.9) | 246 (64.1) | 0.0016*/ | 0.63 (0.47–0.84) |
| A allele | 181 (47.1) | 138 (35.9) | 0.0064* | 1.00 |
| G/G + G/A | 166 (86.5) | 170 (88.5) | 0.5371/ | 0.83 (0.45–1.52) |
| A/A | 26 (13.5) | 22 (11.5) | 2.1496 | 1.00 |
| G/G | 37 (19.3) | 76 (39.6) | 0.00001*/ | 0.36 (0.23–0.58) |
| G/A + A/A | 155 (80.7) | 116 (60.4) | 0.00006* | |
| rs3219476 | ||||
| T/T | 33 (17.2) | 17 (8.9) | 0.0009*/ | 3.81 (1.81–8.04) |
| T/G | 132 (68.8) | 122 (63.5) | 0.0036* | 2.12 (1.26–3.59) |
| G/G | 27 (14.0) | 53 (27.6) | 1.00 | |
| T allele | 198 (51.6) | 156 (40.6) | 0.0024*/ | 1.56 (1.17–2.07) |
| G allele | 186 (48.4) | 228 (59.4) | 0.0096* | 1.00 |
| T/T + T/G | 165 (86) | 139 (72.4) | 0.0011*/ | 2.33 (1.39–3.90) |
| G/G | 27 (14.0) | 53 (27.6) | 0.0044* | 1.00 |
| T/T | 33 (17.2) | 17 (8.9) | 0.013*/ | 2.17 (1.17–4.05) |
| T/G + G/G | 159 (82.8) | 178 (91.1) | 0.0650 | 1.00 |
| rs3219489 | ||||
| G/G | 52 (27.1) | 70 (36.5) | 0.1383/ | 0.61 (0.33–1.13) |
| G/C | 106 (55.2) | 94 (49.0) | 0.5532 | 0.93 (0.52–1.65) |
| C/C | 34 (17.7) | 28 (14.5) | 1.00 | |
| G allele | 210 (54.7) | 234 (60.9) | 0.0795/ | 0.77 (0.58–1.03) |
| C allele | 174 (45.3) | 150 (39.1) | 0.3180 | 1.00 |
| G/G + G/C | 158 (82.3) | 164 (85.5) | 0.4053/ | 0.79 (0.46–1.37) |
| C/C | 34 (17.7) | 28 (14.5) | 1.6212 | 1.00 |
| G/G | 52 (27.1) | 70 (36.5) | 0.0485*/ | 0.65 (0.42–1.00) |
| G/C + C/C | 140 (72.9) | 122 (63.5) | 0.1940 | 1.00 |
| rs3219493 | ||||
| G/G | 164 (85.4) | 161 (83.9) | 0.671/ | 1.13 (0.65–1.97) |
| G/C | 28 (14.6) | 31 (16.1) | 2.6840 | 1.00 |
| C/C | 0 (0) | 0 (0) | ||
| G allele | 356 (92.7) | 353 (91.9) | 0.6844/ | 1.12 (0.66–1.90) |
| C allele | 28 (7.3) | 31 (8.1) | 2.7376 | 1.00 |
| G/G | 164 (85.4) | 161 (83.9) | 0.6712/ | 1.13 (0.65–1.97) |
| G/C + C/C | 28 (14.6) | 31 (16.1) | 1.3424 | 1.00 |
95% CI: 95% confidence intervals.
∗ P value of <0.05 was determined as statistically significant. The chi-square test was performed to obtain the P value.
∗ cP value: P value corrected by Bonferroni correction.