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. 2015 Jul 27;2015:642046. doi: 10.1155/2015/642046

Table 2.

Relationship between the BRAFV600E mutation and clinicopathological factors in PTC.

Total, n (%) BRAFV600E mutation, n (%) χ 2 P value
Mutation (n = 170) Wild (n = 373)
Gender 2.288 0.130
 Female 409 (75.3) 121 (29.6) 288 (70.4)
 Male 134 (24.7) 49 (36.6) 85 (63.4)
Age at diagnosis 0.234 0.629
 <45 219 (40.3) 66 (30.1) 153 (69.9)
 ≥45 324 (59.7) 104 (32.1) 220 (69.7)
Multifocality 0.314 0.575
 No 313 (57.6) 95 (30.4) 218 (69.6)
 Yes 230 (42.4) 75 (32.6) 155 (67.4)
Bilaterality 4.703 0.030
 No 418 (77.0) 121 (28.9) 297 (71.1)
 Yes 125 (23.0) 49 (39.2) 76 (60.8)
Tumor size (cm) 31.109 <0.001
 ≤1 345 (63.5) 79 (22.9) 266 (77.1)
 >1 198 (36.5) 91 (46.0) 107 (54.0)
Extrathyroidal invasion 23.142 <0.001
 No 184 (33.9) 33 (17.9) 151 (82.1)
 Yes 359 (66.1) 137 (38.2) 222 (61.8)
LNM 7.452 0.006
 No 222 (40.9) 55 (24.8) 167 (75.2)
 Yes 321 (59.1) 115 (35.8) 206 (64.2)
AJCC stage 6.741 0.072
 I 434 (79.9) 132 (30.4) 302 (69.6)
 II 6 (1.1) 2 (33.3) 4 (66.7)
 III 70 (12.9) 19 (27.1) 51 (72.9)
 IV 33 (6.1) 17 (51.5) 16 (48.5)