Table 4.
Bone metabolic parameters levels for the CKD patients with osteoporosis by low and high serum Mg levels.
| Case | CKD stage | iPTH (pg/mL) | Ca (mg/dL) | P (mg/dL) | 25(OH)D (ng/mL) | 1,25(OH)2D (pg/mL) | Bone health status |
|---|---|---|---|---|---|---|---|
| Low serum Mg | |||||||
| Diabetes | |||||||
| 1 | 3 | 61.3 | 9.0 | 3.1 | 21.6 | 22.1 | Osteoporosis |
| 2 | 3 | 26.2 | 9.4 | 3.3 | 37.8 | 25.9 | Osteoporosis |
| 3 | 4 | 7.8 | 9.0 | 3.1 | 37.1 | 35.2 | Osteoporosis |
| 4 | 5 | 38.1 | 8.6 | 4.4 | 19.9 | 27.4 | Osteoporosis |
| 5 | 4 | 24.1 | 9.7 | 4.1 | 32.8 | 19 | Osteopenia |
| 6 | 3 | 65.8 | 8.7 | 3.6 | 11.3 | 5.1 | Normal |
| High serum Mg | |||||||
| Diabetes | |||||||
| 1 | 3 | 51.5 | 8.7 | 3.6 | 23.8 | 26.8 | Osteoporosis |
| 2 | 4 | 83.8 | 9.0 | 3.9 | 13.2 | 15.9 | Osteoporosis |
| 3 | 5 | 184.0 | 8.4 | 5.9 | 25.1 | 19.7 | Osteoporosis |
| 4 | 5 | 293.0 | 8.7 | 4.7 | 15.9 | 5.2 | Osteoporosis |
| Nondiabetes | |||||||
| 1 | 5 | 169.0 | 8.7 | 4.2 | 17.8 | 3.4 | Osteoporosis |
(1) For patients with stages 3, 4, and 5 CKD, PTH is in the range of 35–70 pg/mL, 70–110 pg/mL, and 150–300 pg/mL, respectively.
(2) For patients with stages 3 to 4 CKD, serum Ca should be maintained within normal range, 8.9–10.1 mg/dL, and serum P should be within 2.7–4.6 mg/dL. For patients with stage 5 CKD, serum Ca should be 8.4–9.5 mg/dL and serum P target should be 3.3–5.5 mg/dL.
(3) Vitamin D deficiency is defined as a serum 25(OH)D level of less than 20 ng/mL and vitamin D insufficiency is defined as a serum 25(OH)D level of 20 to 30 ng/mL. Serum 1,25(OH)2D deficiency is defined as a serum 1,25(OH)2D level of less than 25.1 ng/mL.