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. 2015 Jul 27;2015:163140. doi: 10.1155/2015/163140

Figure 4.

Figure 4

TSA attenuated LPS-induced cytokine mRNA expression in the hippocampus and cortex of mice. Mice were pretreated with saline (Controls) or TSA (0.3 mg/kg) for 1 h and then intraperitoneally challenged with saline or E. coli LPS (1 mg/kg) (n = 6 in each group). After 24 h they had been treated with LPS, TNF-α, IL-1β, MCP-1, and IDO mRNA expression in the hippocampus and cortex of mice determined using RT-PCR. The lower panel shows the quantification of mRNA expression from six independent experiments. ∗ P < 0.05 compared with the Control group; # P < 0.05 compared with the LPS-only group.