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. 2015 Jul 27;2015:562935. doi: 10.1155/2015/562935

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Copyright © 2015 Nina Pilat et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Recipient but not donor and third-party Treg treatment induces donor-specific tolerance. Donor-specific tolerance was assessed by grafting of donor and third-party skin 4–6 weeks after BMT. Donor skin graft survival was significantly prolonged in BMT recipients treated with recipient Tregs (■ recipient Tregs, n = 4; ◆ donor Tregs, n = 4; ∆ third-party Tregs, n = 3; ○ no Tregs, n = 5). Survival was calculated according to the Kaplan-Meier product limit method and compared between groups using the log-rank test (p < 0.05 for recipient Tregs versus all other groups).