Table 2.
Comparison between the baseline and final (week 16) values for each group.
| Parameters |
Group 1 Insulin + rosiglitazone |
Group 2 Insulin alone |
||||
|---|---|---|---|---|---|---|
| Baseline (n = 30) |
Final (n = 28) |
P | Baseline (n = 31) |
Final (n = 28) |
P | |
| BW (kg) | 66.59 ± 8.6 | 69.96 ± 9.29 | 0.003 | 63.13 ± 8.2 | 65.18 ± 8.20 | 0.001 |
| BMI (kg/m2) | 24.17 ± 2.62 | 25.69 ± 2.57 | 0.002 | 22.97 ± 2.74 | 23.76 ± 2.73 | <0.001 |
| WC (cm) | 83.80 ± 8.26 | 86.61 ± 8.53 | 0.107 | 78.71 ± 9.11 | 80.78 ± 8.09 | 0.109 |
| WHR | 0.85 ± 0.06 | 0.85 ± 0.05 | 0.792 | 0.80 ± 0.06 | 0.82 ± 0.06 | 0.048 |
| SBP (mmHg) | 114 ± 13.63 | 111.6 ± 13.7 | 0.604 | 116 ± 9.37 | 110.5 ± 9.62 | 0.030 |
| DBP (mmHg) | 75.25 ± 9.24 | 70.83 ± 9.11 | 0.061 | 75.95 ± 7.51 | 72.63 ± 7.70 | 0.174 |
| FPG (mg/dL) | 249.1 ± 69.5 | 219.7 ± 97 | 0.460 | 223.2 ± 78.5 | 178 ± 91 | 0.006 |
| HbA1c (%) | 9.22 ± 1.77 | 9.09 ± 1.40 | 0.239 | 8.75 ± 1.14 | 8.46 ± 1.19 | 0.050 |
| eGDR (mg/kg/min) | 8.53 ± 2.70 | 8.36 ± 2.45 | 0.185 | 9.25 ± 3.18 | 9.22 ± 3.20 | 0.235 |
| Urea (mg/dL) | 25.50 ± 7.17 | 26.66 ± 6.2 | 0.032 | 25.52 ± 6.03 | 27.84 ± 4.96 | 0.042 |
| Cr (mg/dL) | 0.83 ± 0.16 | 0.82 ± 0.26 | 0.935 | 0.86 ± 0.12 | 0.90 ± 0.31 | 0.602 |
| ALT (IU/L) | 18.25 ± 11.4 | 13.55 ± 4.3 | 0.033 | 15.85 ± 9.85 | 17.52 ± 13.3 | 0.912 |
| Total-C (mg/dL) | 172.8 ± 36.2 | 169.0 ± 31.8 | 0.935 | 177.3 ± 33.8 | 170.1 ± 34.5 | 0.678 |
| HDL-C (mg/dL) | 45 ± 5.90 | 47.80 ± 9.37 | 0.285 | 47.00 ± 9.35 | 51.47 ± 10.60 | 0.038 |
| LDL-C (mg/dL) | 105 ± 27.12 | 98.86 ± 27.89 | 0.688 | 111.15 ± 24.17 | 107.45 ± 30.1 | 0.668 |
| TG (mg/dL) | 113 ± 77.91 | 111.20 ± 52.41 | 0.971 | 79.47 ± 42.95 | 81.57 ± 27.14 | 0.821 |
| FFA (mEq/L) | 0.57 ± 0.43 | 0.53 ± 0.28 | 0.913 | 0.49 ± 0.25 | 0.47 ± 0.26 | 0.601 |
| ACR (mg/min) | 35.50 ± 42.91 | 23.57 ± 17.65 | 0.136 | 19.36 ± 19.00 | 12.54 ± 10.72 | 0.667 |
| Hgb (g/dL) | 13.72 ± 1.98 | 13.16 ± 1.98 | 0.015 | 13.74 ± 1.64 | 13.61 ± 1.04 | 0.838 |
| HCT (%) | 40.55 ± 5.48 | 39.06 ± 5.42 | 0.067 | 40.53 ± 4.44 | 40.65 ± 2.69 | 0.428 |
| Resistin | 6.96 ± 3.06 | 4.99 ± 2.64 | 0.006 | 7.16 ± 2.30 | 5.57 ± 2.48 | 0.031 |
| Leptin | 25.8 ± 17.6 | 20.1 ± 12.55 | 0.006 | 16.72 ± 16.1 | 14.0 ± 13.4 | 0.007 |
| Adiponectin | 17.48 ± 10.71 | 19.81 ± 11.21 | 0.145 | 11.90 ± 5.23 | 15.98 ± 9.47 | 0.948 |
| Insulin dose (units/day) | 64.45 ± 16.31 | 65.88 ± 15.29 | NS | 53.33 ± 13.45 | 52.78 ± 11.07 | NS |
BW: body weight; BMI: body mass index; WC: waist circumference; WHR: waist-to-hip ratio; SBP: systolic blood pressure; DBP: diastolic blood pressure; FPG: fasting plasma glucose; HbA1c: glycosylated hemoglobin; eGDR: estimated glucose disposal rate; CR: creatinine; AST: aspartate aminotransferase; ALT: alanine aminotransferase; Total-C: total cholesterol; HDL-C: high-density lipoprotein cholesterol; LDL-C: low-density lipoprotein cholesterol; TG: triglycerides; FFA: free fatty acids; ACR: albumin/creatinine ratio; Hgb: hemoglobin; Hct: hematocrit.