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Model of PRL tumoral progression toward an aggressive phenotype. N, normal cell; P1–3, predisposed cells 1–3; NA, non-aggressive tumors; A, aggressive tumors; M, malignant tumors (carcinomas). As described in the main text, miRNA down regulation induces a specific progression toward a malignant phenotype involving secondary genetic alterations, whereas absence of miRNA deregulation leads to a non-aggressive phenotype.
