. 2015 Aug 10;9:279. doi: 10.3389/fnins.2015.00279

Table 4.

Serotonin receptor effects on cognitive function.

Drug	Dose (mg/kg)	Route	Target receptor	Action	Species	Strain	Sex	Task	Effect	References
8-OHDPAT	0.03–0.09	i.p.	5-HT_1A	Agonist	Rat	Wistar Han	M	MWM	No effect	Riekkinen et al., 1994
8-OHDPAT	0.1, 0.3	s.c.	5-HT_1A	Agonist	Rat	Wistar	M	MWM	Impairment	Meijer et al., 1998
8-OHDPAT	0.25	i.p.	5-HT_1A	Agonist	Rat	Sprague Dawley	M	Mod MWM	Impairment	Kant et al., 1998
8-OHDPAT	2	i.p.	5-HT_1A	Agonist	Rat	Sprague Dawley	M	SA	Impairment	Seibell et al., 2003
8-OHDPAT	0.125–2	i.p.	5-HT_1A	Agonist	Rat	Sprague Dawley	M	SA	Impairment	Ulloa et al., 2004
8-OHDPAT	0.125–2	i.p.	5-HT_1A	Agonist	Rat	Sprague Dawley	F	SA	No effect	Ulloa et al., 2004
8-OHDPAT	0.25–0.5	i.p.	5-HT_1A	Agonist	Rat	Wistar	M	Auto	Impairment	Meneses, 2007
8-OHDPAT	1	i.p.	5-HT_1A	Agonist	Rat	Wistar	M	Auto	No effect	Meneses, 2007
8-OHDPAT	0.031–0.25	i.p.	5-HT_1A	Agonist	Rat	Wistar	M	Auto	Improvement	Meneses and Hong, 1999
8-OHDPAT	0.062	i.p.	5-HT_1A	Agonist	Rat	Wistar	M	Auto	Improvement	Meneses et al., 1997
8-OHDPAT	1	i.p.	5-HT_1A	Agonist	Rat	Wistar	M	Auto	No effect	Meneses and Hong, 1999
8-OHDPAT	0.1–1	s.c.	5-HT_1A	Agonist	Rat	Wistar	M	NOR	Impairment	Pitsikas et al., 2005
Buspirone	10	i.p.	5-HT_1A	Agonist	Rat	Sprague Dawley	M	Mod MWM	Impairment	Kant et al., 1998
S15535	0.16–10	s.c.	5-HT_1A	Partial agonist	Rat	Wistar	M	SR	Improvement	Millan et al., 2004
S15535	0.16–0.63	s.c.	5-HT_1A	Partial agonist	Mouse	C57BL/6	M	DNMTS	Improvement	Millan et al., 2004
S15535	1.25–5	p.o.	5-HT_1A	Partial agonist	Rat	old Wistar	M	DNMTS	Improvement	Millan et al., 2004
WAY100635	0.3–1	i.p.	5-HT_1A	Antagonist	Rat	CD-COBS	M	NOR	No effect	Pitsikas et al., 2003
WAY100635	0.3–1	s.c.	5-HT_1A	Antagonist	Rat	Wistar	M	NOR	No effect	Pitsikas et al., 2005
WAY100635	0.001–1	i.p.	5-HT_1A	Antagonist	Rat	Wistar	M	Auto	No effect	Meneses and Hong, 1999
WAY100135	5–20	i.p.	5-HT_1A	Antagonist	Rat	Wistar	M	Auto	No effect	Meneses and Hong, 1999
DOI	1	i.p.	5-HT_2A/2C	Agonist	Rat	Sprague Dawley	M	SA	No effect	Seibell et al., 2003
DOI	0.1–0.25	i.p.	5-HT_2A/2C	Agonist	Rat	Sprague Dawley	M	Mod MWM	No effect	Kant et al., 1998
DOI	0.1–1	i.p.	5-HT_2A/2C	Agonist	Rat	Wistar	M	Auto	Impairment	Meneses, 2007
DOI	0.1	i.p.	5-HT_2A/2C	Agonist	Rat	Wistar	M	Auto	Improvement	Meneses et al., 1997
ketanserin	0.001	i.p.	5-HT₂	Antagonist	Rat	Wistar	M	Auto	Improvement	Meneses et al., 1997
M100907	0.08	i.p.	5-HT_2A	Antagonist	Rat	Wistar	M	DALT	No effect	Papakosta et al., 2013
M100907	0.1–3	i.p.	5-HT_2A	Antagonist	Rat	Wistar	M	Auto	No effect	Meneses et al., 1997
SB242084	0.5	i.p.	5-HT_2C	Antagonist	Rat	Wistar	M	DALT	No effect	Papakosta et al., 2013

Auto, autoshaping; DALT, delayed alternation; DNMTS, delayed non-match to sample; F, female; M, male; MWM, Morris water maze; Mod, modified; NOR, novel object recognition; SA, spontaneous alternation; SR, social recognition.