Table 5.

Quartiles of the VV/SV z Score and Impairment Combinations: AGES-Reykjavik Study

	Model 1					Model 2
	Quartiles of the VV/SV z Score				p trend	Quartiles of the VV/SV z Score				p trend
	1	2	3	4		1	2	3	4
Gait + cognition	1.0	1.5 (0.8–2.8)	2.0a (1.1–3.7)	2.5a (1.3–4.6)	0.002a	1.0	1.5 (0.7–3.2)	1.9 (0.9–3.9)	2.6a (1.3–5.3)	0.006a
Gait + bladder dysfunction	1.0	1.2 (0.5–3.1)	3.3a (1.5–7.4)	1.5 (0.6–3.7)	0.09	1.0	1.3 (0.5–3.4)	3.0a (1.2–7.4)	1.6 (0.6–4.3)	0.1
Cognition + bladder dysfunction	1.0	0.8 (0.3–1.9)	2.5a (1.2–5.2)	1.5 (0.7–3.3)	0.06	1.0	0.7 (0.3–1.8)	1.9 (0.8–4.3)	1.3 (0.6–3.3)	0.2
Triad (gait + cognition + bladder dysfunction)	1.0	0.9 (0.2–3.8)	4.9a (1.6–14.8)	1.9 (0.6–6.6)	0.05	1.0	0.9 (0.2–4.3)	4.9a (1.4–18.0)	2.2 (0.5–8.8)	0.07

VV = ventricular volume; SV = sulcal cerebrospinal fluid volume; AGES = Age, Gene/Environment Susceptibility.

The first quartile of the VV/SV z score, indicated in the table as 1.0, served as the reference group. Model 1 was adjusted for age and sex. Model 2, the fully adjusted model, was adjusted for age, sex, education, smoking, body mass index, depression, hypertension, coronary heart disease, degenerative myelopathy, total white matter lesions volume, history of peripheral artery disease, and brain volume corrected for total intracranial volume.

^aIndicates a significant relationship (p < 0.05).