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. Author manuscript; available in PMC: 2016 Aug 1.
Published in final edited form as: J Oral Biosci. 2015 Aug 1;57(3):143–147. doi: 10.1016/j.job.2015.05.001

Figure 2. Regulation of the Ral GTPase.

Figure 2

GTP-bound Ras activates Ral-GEF, which catalyzes binding of Ral to GTP (“on”). GTP-bound Ral regulates a series of cellular processes, including anchorage-independent proliferation. Ral-GAP catalyzes the hydrolysis of GTP to GDP by Ral (“off”). κB-Ras enhances this Ral-GAP activity.