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. Author manuscript; available in PMC: 2016 Jul 29.
Published in final edited form as: Cell Syst. 2015 Jul 29;1(1):37–50. doi: 10.1016/j.cels.2015.07.001

Figure 7. Model of initiation and reinforcement of actin assembly during cell protrusions mediated by multiple, functionally overlapping, assembly promoting pathways.

Figure 7

The formin mDia1 is recruited to the leading edge of the cell before protrusion onset, initiating linear growth of the lamellipodial network. Recruitment of Arp2/3 sensitive to membrane tension then promotes sustained exponential growth of the network, supported by additional assembly factors.