Extended Data Figure 9. Cell type composition.

a, For each class of gene expression change (x-axis), shown is the enrichment of cell-type-specific gene markers from published datasets^48–50. The macrophage and monocyte categories are computed relative to microglia^49,50. The enrichment is calculated relative to the genes that do not change in expression level in the CK-p25 mice. Cells in the heatmap are labeled based on the −log₁₀(P value) (hypergeometric t-test). Cases where no genes overlapped are shown in grey. b, Summary of a, showing the inferred change in cell type composition across time.