Figure 1.
1a: top panel- Hepatic DDAH-1 is located within the cytoplasm of hepatocytes of human liver; DDAH-1 levels are markedly decreased in cirrhotic liver (right side image) compared to a healthy liver (left side image).
Similarly, in the BDL rat model of cirrhosis, DDAH-1 is predominantly located in the hepatocyte cell fraction from rat liver as compared with the non-hepatocyte cell (NPC) fraction (1b: left panel), and DDAH-1 protein levels are markedly reduced in BDL rat liver compared to sham (1c: centre panel). By contrast, hepatic DDAH-2 protein levels are increased in BDL rat liver compared to sham (1d: right panel).