Table 1.
Patients | Controls | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
P | A | F (%) | P | A | F(%) | p | OR | 95% CI | ||
Allele frequencies | ||||||||||
001 | Euro | 46 | 160 | 22.3 | 22 | 156 | 12.4 | 0.007 | 2.04 | 1.17 – 3.54 |
Afro | 29 | 75 | 27.9 | 18 | 81 | 18.2 | 0.070 | 1.74 | 0.89 – 3.39 | |
Total | 75 | 235 | 24.2 | 40 | 237 | 14.4 | 0.002 | 1.89 | 1.24 – 2.89 | |
Carrier frequencies | ||||||||||
001 | Euro | 39 | 65 | 37.5 | 20 | 70 | 22.2 | 0.015 | 2.10 | 1.11 – 3.97 |
Afro | 24 | 28 | 46.2 | 17 | 34 | 33.3 | 0.129 | 1.71 | 0.77 – 3.81 | |
Total | 63 | 93 | 40.4 | 37 | 104 | 26.2 | 0.010 | 1.90 | 1.16 – 3.11 | |
Genotypes | ||||||||||
001/001 | Total | 12 | 144 | 7.7 | 3 | 138 | 2.1 | 0.025 | 3.83 | 1.06 – 13.87 |
001/other | Total | 51 | 105 | 32.7 | 34 | 107 | 24.1 | 0.087 | 1.55 | 0.93 – 2.60 |
SNPs | ||||||||||
322A | Euro | 40 | 64 | 38.5 | 45 | 45 | 50.0 | 0.071 | 0.63 | 0.35 – 1.11 |
Afro | 27 | 25 | 51.9 | 24 | 27 | 47.1 | 0.308 | 0.70 | 0.35 – 1.38 | |
337G | Euro | 29 | 75 | 27.9 | 24 | 66 | 26.7 | 0.490 | 1.06 | 0.56 – 2.00 |
Afro | 9 | 43 | 17.3 | 15 | 36 | 29.4 | 0.146 | 0.50 | 0.20 – 1.28 | |
1190T | Euro | 40 | 64 | 38.5 | 49 | 44 | 54.4 | 0.018 | 0.52 | 0.29 – 0.93 |
Afro | 23 | 29 | 44.2 | 21 | 30 | 41.2 | 0.752 | 1.13 | 0.52 – 2.47 |
P=presence; A=absent; F=frequency, p=p-value; OR=odds ratio, CI=confidence interval. For simplification, KIR3DL2*001 is represented as 001. Bold highlights the significant associations.