Table 2.
Association of KIR3DL2 variants and HLA-A ligands with pemphigus foliaceus
| Patients | Controls | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| P | A | F (%) | P | A | F(%) | p | OR | 95% CI | ||
| Carrier frequencies | ||||||||||
| HLA-A ligand | Euro | 47 | 59 | 44.3 | 23 | 46 | 33.3 | 0.146 | 1.59 | 0.85 – 2.99 |
| Afro | 23 | 35 | 39.7 | 13 | 21 | 38.2 | 0.887 | 1.06 | 0.44 – 2.53 | |
| Total | 70 | 94 | 42.7 | 36 | 67 | 35.0 | 0.210 | 1.36 | 0.83 – 2.31 | |
|
3DL2*001+ HLA-A ligand |
Euro | 18 | 61 | 22.8 | 4 | 51 | 7.3 | 0.017 | 3.76 | 1.20 – 11.82 |
| Afro | 6 | 29 | 17.1 | 3 | 25 | 10.7 | 0.360 | 1.72 | 0.39 – 7.61 | |
| Total | 24 | 90 | 21.1 | 7 | 76 | 8.4 | 0.016 | 2.89 | 1.18 – 7.09 | |
|
1190T+HLA-A ligand |
Euro | 10 | 69 | 12.7 | 8 | 48 | 14.3 | 0.488 | 0.87 | 0.32 – 2.36 |
| Afro | 5 | 30 | 14.3 | 3 | 25 | 10.7 | 0.569 | 1.19 | 0.26 – 5.44 | |
| Total | 15 | 99 | 13.2 | 11 | 73 | 13.1 | 0.582 | 1.00 | 0.44 – 2.32 | |
HLA-A ligand: presence of A3 and/or A11. P=presence; A=absent; F=frequency, p=p-value; OR=odds ratio, CI=confidence interval. For simplification, KIR3DL2*001 is represented as 001. Bold highlights the significant association