Fig. 4. Differential modulation of astrocyte scratch responses by rapamycin is ECM dependent.
Astrocytes grown on different ECM substrates were scratched and treated with either rapamycin (5 μg/mL) or vehicle. Measurements of scratch wound recovery after 24 h were compared with control-treated cultures on the same ECM substrate. Rapamycin was found to only impair scratch wound recovery of astrocytes grown on TnC (*P < 0.005).