Fig. 1.
Some biologic functions of annexin A2. At the cell surface, annexin A2 binds to protein S100A10 (p11). The heterotetrameric complex associates with the plasma membrane through calcium linkages (shown in red) with membrane phospholipid, and supports the assembly of plasminogen (Plg) and tissue plasminogen activator (tPA), leading to the efficient generation of the fibrinolytic serine protease, plasmin (PN). Plasmin enables fibrinolysis and angiogenesis. Within the cell, the (annexin A2-p11)2 complex participates in repair of injured lysosomal membranes (L) by “annexing” membrane from cytoplasmic vesicles (V).