Table 4.
Exonic MBL2 Genotypes for the Main Survival Analysis Subgroups
| MBL2 Genotype | Sepsis 28 d Deaths | Sepsis 28 d Survivors | Sepsis 6 mo Deaths | Sepsis 6 mo Survivors | Pneumococcal CAP Sepsis 28 d Deaths | Pneumococcal CAP Sepsis 28 d Survivors |
|---|---|---|---|---|---|---|
| A/A (%) | 209 (58.5) | 857 (57.8) | 157 (59.2) | 406 (57.7) | 29 (64.4) | 108 (54) |
| A/B (%) | 81 (22.7) | 336 (22.7) | 58 (21.9) | 164 (23.3) | 8 (17.8) | 46 (23) |
| A/C (%) | 10 (2.8) | 43 (2.9) | 6 (2.3) | 20 (2.8) | 0 | 8 (4.0) |
| A/D (%) | 37 (10.4) | 164 (11.1) | 32 (12.1) | 78 (11.1) | 6 (13.3) | 27 (13.5) |
| Sum A/O (%) | 128 (35.9) | 543 (36.7) | 96 (36.2) | 262 (37.2) | 14 (31.1) | 81 (40.5) |
| B/B (%) | 3 (0.8) | 39 (2.6) | 5 (1.9) | 17 (2.4) | 0 | 9 (4.5) |
| B/C (%) | 2 (0.6) | 5 (0.3) | 0 | 0 | 0 | 0 |
| B/D (%) | 9 (2.5) | 30 (2.0) | 4 (1.5) | 16 (2.3) | 2 (4.4) | 2 (1.0) |
| C/C (%) | 0 | 1 (0.1) | 0 | 1 (0.1) | 0 | 0 |
| C/D (%) | 3 (0.8) | 4 (0.3) | 2 (0.8) | 2 (0.3) | 0 | 0 |
| D/D (%) | 3 (0.8) | 3 (0.2) | 1 (0.4) | 0 | 0 | 0 |
| Sum O/O (%) | 20 (5.6) | 82 (5.5) | 12 (4.5) | 36 (5.1) | 2 (4.4) | 11 (5.5) |
| Total | 357 | 1482 | 265 | 704 | 45 | 200 |
| P-value for AA,AO,OO genotypic test | .937 | .697 | .488 | |||
Percentages of genotype distributions are shown in brackets. In addition to the genotypic test, we have also performed the allelic, recessive, dominant and heterozygous tests for the AA, AO, OO genotypes, and all individual exonic SNPs (all P-values were nonsignificant following correction for multiple testing).
Abbreviations: CAP, community-acquired pneumonia; SNP, single nucleotide polymorphism.