Table 6.
Exonic MBL2 Genotypes for the Susceptibility Analysis Subgroups
| MBL2 Genotype | UK Controls | UK CAP Sepsis Cases | UK Pneumococcal CAP Sepsis Cases |
|---|---|---|---|
| A/A (%) | 262 (54.9) | 295 (59.5) | 55 (57.9) |
| A/B (%) | 122 (25.6) | 114 (23.0) | 23 (24.2) |
| A/C (%) | 20 (4.2) | 10 (2.0) | 2 (2.1) |
| A/D (%) | 54 (11.3) | 49 (9.9) | 9 (9.5) |
| Sum A/O (%) | 196 (41.1) | 173 (34.9) | 34 (35.8) |
| B/B (%) | 6 (1.3) | 13 (2.6) | 5 (5.3) |
| B/C (%) | 2 (0.4) | 0 | 0 |
| B/D (%) | 8 (1.7) | 10 (2.0) | 1 (1.1) |
| C/C (%) | 0 | 0 | 0 |
| C/D (%) | 1 (0.2) | 4 (0.8) | 0 |
| D/D (%) | 2 (0.4) | 1 (0.2) | 0 |
| Sum O/O (%) | 19 (4.0) | 28 (5.6) | 6 (6.4) |
| Total | 477 | 496 | 95 |
| P Value for AA,AO,OO genotypic test | NA | .170 | .530 |
Percentages of genotype distributions are shown in brackets. In addition to the genotypic test, we have also performed the allelic, recessive, dominant and heterozygous tests for the AA, AO, OO genotypes, and all individual exonic SNPs (All P-values were nonsignificant following correction for multiple testing).
Abbreviations: CAP, community-acquired pneumonia; NA, not applicable; SNP, single nucleotide polymorphism.